Nanodiamond as a Cytokine Sponge in Infectious Diseases.

Cytokine release syndrome (CRS) is a systemic inflammatory response resulting in overexpression of cytokines in serum and tissues, which leads to multiple-organ failure. Due to rapid aggravation of symptoms, timely intervention is paramount; however, current therapies are limited in their capacity to address CRS. Here, we find that the intravenous injection of highly purified detonation-synthesized nanodiamonds (DND) can act as a therapeutic agent for treating CRS by adsorbing inflammatory cytokines. Highly purified DNDs successfully inactivated various key cytokines in plasma from CRS patients with pneumonia, septic shock, and coronavirus disease 2019 pandemic (COVID-19). The intravenous injection of the DND samples in a mouse sepsis model by cecal ligation and puncture significantly improved survival rates and prevented tissue damage by reducing the circulating inflammatory cytokines. The results of this study suggest that the clinical application of highly purified DND can provide survival benefits for CRS patients by adsorbing inflammatory cytokines.

Policy responses to COVID-19 and discrimination against foreign nationals in South Korea

While South Korean racism and discrimination against migrant workers and foreign brides are not new phenomenon, some early policies adopted by the central and local governments to mitigate the impact of Covid-19 have once again revealed the country’s deep-seated xenophobia. This paper focuses on three government policies – mask rationing, universal disaster relief funds, and local government subsidies – that were adopted during the first wave of coronavirus in South Korea from February until June 2020, when supplies were insufficient and the economy was most severely affected. This paper highlights the fact that government policies were based on nationality, which led to the exclusion of foreign nationals, even long-time taxpaying residents. Such institutional discrimination was blatant, considering the country’s decades-long discussion of multiculturalism. This paper points out that, as a country with a very low number of naturalized citizens, discrimination against foreign nationals not only reflects South Korea’s perceived boundaries of in-groups and out-groups, but also demonstrates the lack of a legal basis that prohibits discriminatory practices. [ABSTRACT FROM AUTHOR] Copyright of Critical Asian Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)